Preparation and receptor binding affinities of cyclic C-terminal neurotensin (8-13) and (9-13) analogues

J T Lundquist 4th; T A Dix

doi:10.1016/s0960-894x(99)00420-5

Preparation and receptor binding affinities of cyclic C-terminal neurotensin (8-13) and (9-13) analogues

Bioorg Med Chem Lett. 1999 Sep 6;9(17):2579-82. doi: 10.1016/s0960-894x(99)00420-5.

Authors

J T Lundquist 4th¹, T A Dix

Affiliation

¹ Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston 29425, USA.

PMID: 10498212
DOI: 10.1016/s0960-894x(99)00420-5

Abstract

Cyclic analogues of neurotensin (NT) C-terminal fragments NT(8-13) and NT(9-13) were produced via intramolecular nucleophilic substitution of the Tyr(11) phenoxide anion on a 6-bromohexanoyl side chain substituted at position 8 or 9 and tested for NT receptor binding affinity.

MeSH terms

Amino Acid Sequence
Humans
Neurotensin / analogs & derivatives
Neurotensin / chemical synthesis*
Neurotensin / metabolism
Peptide Fragments / chemical synthesis*
Peptide Fragments / metabolism
Protein Binding
Receptors, Neurotensin / metabolism*

Substances

Peptide Fragments
Receptors, Neurotensin
Neurotensin